Introduction: Parkinson disease (PD) is one of the most Prevalent degenerative disease of the CNS. Its prevalence is about 360 per 100000 and increase with age. Beside the motor, cognition and emotional derangements autonomic disturbances are also encountered, such as orthostatic hypotension, cool skin, constipation, hyperhydrosis, and occasionally cardiac arrhythmia. The sympathetic skin response (SSR) was used to evaluate sympathetic sudomotor activity in PD.Materials and Methods: this cross sectional, case-control study was performed on 31 PD patients and 38 healthy controls, in 2004. We recorded SSRs to electric stimulation of median nerve at palm. We measured latency of SSRs and compare the results between two groups according to t-student test.Results: The mean age of two groups were matched at baseline (P=0.81). The mean latency of SSRs was 1.93 (0.52) in case group and 1.50 (0.20) in healthy controlled group (P<0.001). We also found that age of patients (P=0.61), duration of affliction (P=0.65) and intensity of rest tremor (P=0.92) had not any influence on rate of abnormal SSR.Conclusion: The degenerative process in PD, involve the sudomotor system as reflected by increased latency of SSR without a correlation to PD symptom duration, tremor intensity and age of patients.